But the Nationals took the lead in the bottom of the inning off Cardinals starter Michael Wacha. Bryce Harper had an RBI single, while Wilson Ramos drove in two runs with a single to right.
The Cardinals made it a one-run game against a combination of Nats relievers -- Oliver Perez, Blake Treinen and Felipe Rivero -- in the top of the seventh inning, when Matt Adams hit a sacrifice fly.
But it was all Nats after that. They would score seven runs in the next two innings. Jayson Werth highlighted the scoring with a pinch-hit grand slam in the seventh.
MOMENTS THAT MATTERED
Rivero saves day: With the Nationals up, 3-1, the Cardinals had the bases loaded with one out when Rivero entered the game. After Adams hit his sac fly to make it a one-run game, Rivero got Randal Grichuk to fly out to left fielder Chris Heisey to end the threat.
STL@WSH: Adams sends a sacrifice fly to right field
Matt Adams sends a sacrifice fly to right field, scoring Aledmys Diaz and cutting the Cardinals' deficit to 3-2
Bullpen blues: When manager Mike Matheny turned to his bullpen Sunday, the Cardinals trailed only 3-2, with plenty of time left for a comeback. But Jonathan Broxton allowed Rendon's homer, followed by back-to-back singles and, after striking out Heisey, was pulled in favor of Dean Kiekhefer. The lefty walked Ben Revere, then served up Werth's grand slam. Tyler Lyons entered in the eighth and promptly gave up a Rendon single followed by a Ramos two-run shot. In total, the Cardinals' bullpen pitched two innings and allowed seven runs on eight hits, including three long balls.
STL@WSH: Ramos knocks home run to left
Wilson Ramos sends a home run off of Tyler Lyons for his sixth of the season, making it 10-2
Big slam from Werth: The Nationals put the game out of reach in the seventh. Rendon led off with a home run and Werth hit his first career pinch-hit grand slam to make it a six-run game. It's only the second pinch-hit grand slam in Nats history. Justin Maxwell was the first to do it, on Sept. 11, 2007, against the Marlins.
STL@WSH: Werth crushes a grand slam to center in 7th
Jayson Werth launches a grand slam to center off Dean Kiekhefer, giving the Nationals an 8-2 lead in the 7th inning #PapaSlam
Fourth inning stings Wacha: Wacha allowed three earned runs in six innings for his first quality start since May 3 but took the loss thanks to one bad inning. After Wacha retired the Nationals without a hit in the first three innings, Washington hit the righty hard in the fourth, with two singles and two doubles yielding three runs. Outside of the fourth, Wacha did not allow a hit.
REPLAY REVIEW
The crew chief called for a review of Rendon's seventh-inning home run, which appeared to just clear the fence in right field. After a brief review, the call was confirmed, giving Rendon his fourth homer of the season.
WHAT'S NEXT
Cardinals: The Cardinals will travel to Milwaukee for a three-game series against the Brewers, which begins Monday afternoon at 1:10 CT. For the first game, St. Louis will start Carlos Martinez, who has allowed 14 runs in 15 innings over his past three outings. Martinez has not started against the Brewers yet this year but has a 1.34 ERA against them in his career.
Nationals: Washington travels to Philadelphia for a three-game series against the Phillies starting Monday at 7:05 p.m. ET. Tanner Roark, who pitches the first game, tossed seven scoreless innings against the Phillies at Nationals Park on April 28, but he didn't get a decision as Washington lost the game, 3-0. This will be Roark's first start at Citizens Bank Park this season.
Watch every out-of-market regular-season game live on MLB.TV.
Alex Putterman is a reporter for MLB.com based in Washington and covered the Cardinals on Sunday.
This story was not subject to the approval of Major League Baseball or its clubs.
Strasburg moves to 9-0 as Nats rout Cards
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