The Giants cut the lead in half -- and chased Greinke from the game -- in the bottom of the inning when Gregor Blanco tripled with one out and scored on Angel Pagan's single to left.
MOMENTS THAT MATTERED
Big hit: After providing plenty of power last year following his trade to Arizona from Seattle, Castillo had been quiet in 2016. He entered Wednesday night's game hitting .209, but he rediscovered his clutch ways with his seventh-inning homer.
Stranded: The Giants had Greinke on the ropes early when the first two batters in the first inning reached base, with the heart of the order coming up. But Greinke got Buster Posey to fly out before Brandon Belt and Brandon Crawford struck out swinging. San Francisco also came up empty after getting a runner to third with less than two outs in both the third and fourth.
WHAT'S NEXT
D-backs: Shelby Miller starts for the D-backs on Thursday afternoon in the series finale with the Giants, which starts at 12:45 p.m. MST. Miller's last outing lasted just 1 2/3 innings after he banged his right hand on the pitcher's mound twice during Andrew Cashner's at-bat and was forced to leave the game..
Giants: Right-hander Johnny Cueto pitches the series finale against Arizona at AT&T Park on Thursday at 12:45 p.m. PT. Cueto is attempting to become the first San Francisco pitcher to win his first four starts since Bill Swift did it in 1992.
Watch every out-of-market regular-season game live on MLB.TV.
Steve Gilbert is a reporter for MLB.com. Follow him on Twitter @SteveGilbertMLB. Mike Wagaman is a contributor to MLB.com. This story was not subject to the approval of Major League Baseball or its clubs.
Greinke comes out on top in battle of aces
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